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Anti Reverse Transcriptase and Anticancer activity of stem ethanol extracts of Excoecaria agallocha (Euphorbiaceae)

Authors:

RC Patil,

Department of Microbiology, Bhavan’s College, Andheri (W), Mumbai, Maharashtra, IN
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Sonal M Manohar,

Department of Life Sciences, University of Mumbai, Santacruz (E), Mumbai, Maharashtra, IN
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Madhav V Upadhye ,

Department of Life Sciences, University of Mumbai, Santacruz (E), Mumbai, Maharashtra, IN
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VI Katchi,

Department of Zoology, Bhavan’s College, Andheri (W), Mumbai, Maharashtra, IN
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Asha J Rao,

Department of Zoology, Bhavan’s College, Andheri (W), Mumbai, Maharashtra, IN
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Abhishek Mule,

Department of Microbiology, Bhavan’s College, Andheri (W), Mumbai, Maharashtra, IN
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Alpana S Moghe

Department of Cell and Molecular Biology, Rajeev Gandhi Institute of IT and Biotechnology, Bharthi Vidyapeeth University, Pune, Maharashtra, IN
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Abstract

Excoecaria agallocha L. (Euphorbiaceae) is a mangrove plant widely used in folklore medicine for the treatment of several diseases. In the present study anti HIV and anticancer properties of active fraction of stem ethanol extracts of the plant were investigated. The fraction showed significant anti-reverse transcriptase activity in the enzyme-based direct binding assay which was as good as that of the standard synthetic inhibitor. Anticancer activity of the same fraction was determined using MTS in vitro assay. It showed potent cytotoxicity against pancreatic cancer cell lines Capan-1 and Miapaca-2 with IC50 values of 4 μg/ml and 7 μg/ml respectively. These results clearly indicate strong anti HIV and anticancer properties in stem extracts of E. agallocha.  

Key words: mangrove; pancreatic cancer; activity guided fractionation; anti HIV properties

DOI: http://dx.doi.org/10.4038/cjsbs.v40i2.3931

CJSBS 2011; 40(2): 147-155

How to Cite: Patil, R. et al., (2012). Anti Reverse Transcriptase and Anticancer activity of stem ethanol extracts of Excoecaria agallocha (Euphorbiaceae). Ceylon Journal of Science (Biological Sciences). 40(2), pp.147–155. DOI: http://doi.org/10.4038/cjsbs.v40i2.3931
Published on 13 Jan 2012.
Peer Reviewed

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